Abstract
•. UK and national guidelines recommend skeletal survey for diagnosis of multiple myeloma.•. Patients with negative skeletal survey require further imaging to rule out occult disease (i.e. diffuse marrow infiltration/small lesions with little cortical destruction).•. MRI has greater sensitivity and specificity than fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which is maximised when whole body coverage is employed.•. Tumour burden demonstrated by MRI and FDG PET/CT provides prognostic information.•. Neither plain film nor CT can be used to assess treatment response.•. Conventional MRI provides a good subjective assessment of treatment response, which is particularly useful in non-secretory myeloma.•. Both diffusion-weighted MRI and FDG PET/CT are attractive quantitative measures of disease, but neither has been fully validated in multiple myeloma.•. MRI is the modality of choice for imaging suspected cord compression and differentiating benign from malignant vertebral compression fractu...
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