Image reconstruction for synchronous data acquisition in fluorescence molecular tomography.

Abstract

The present full-angle, free-space fluorescence molecular tomography (FMT) system uses a step-by-step strategy to acquire measurements, which consumes time for both the rotation of the object and the integration of the charge-coupled device (CCD) camera. Completing the integration during the rotation is a more time-efficient strategy called synchronous data acquisition. However, the positions of sources and detectors in this strategy are not stationary, which is not taken into account in the conventional reconstruction algorithm. In this paper we propose a reconstruction algorithm based on the finite element method (FEM) to overcome this problem. Phantom experiments were carried out to validate the performance of the algorithm. The results show that, compared with the conventional reconstruction algorithm used in the step-by-step data acquisition strategy, the proposed algorithm can reconstruct images with more accurate location data and lower relative errors when used with the synchronous data acquisition strategy.