Image quality of the CAIPIRINHA-Dixon-TWIST-VIBE technique for ultra-fast breast DCE-MRI: Comparison with the conventional GRE technique

Abstract

PurposeThe aim of this study was to evaluate image quality of the CAIPIRINHA-Dixon-TWIST-Volume-Interpolated Breath-hold Examination (CDT-VIBE) technique for ultra-fast breast dynamic contrast enhanced (DCE) MRI with respect to conventional Gradient-Recalled Echo (GRE) technique. MethodsA total of 58 patients underwent a DCE-MRI based on CDT-VIBE sequence (temporal resolution: 11.9 s), immediately followed by 1 phase of a conventional T1 weighted GRE sequence (acquisition time: 68 s). The Signal-to-Noise Ratio (SNR) on phantom images, lesion/parenchyma signal ratio (LPSR), image quality, and morphological characterization were compared between the last phase of CDT-VIBE and conventional GRE images. The image quality was assessed by visual grading analysis (VGA). Reader agreement was assessed using Kappa analysis. ResultsThere was no significant difference in SNR (phantom) or LPSR (patient) between CDT-VIBE and conventional GRE images (P > 0.05). Significant parallel acquisition technique (PAT) noise and mild blurriness was observed on CDT-VIBE images. Visual grading analysis (VGA) confirmed significantly worse ratings for CDT-VIBE compared to the conventional GRE sequence in terms of PAT noise, lesion’s internal feature clarity, and therefore overall image quality (area under contrast curve [AUC] values: 0.578 ‒ 0.764, P < 0.05), but edge sharpness and lesion conspicuity were equivalent (P > 0.05). Kappa analysis revealed good agreement on image quality scores (к = 0.725 ‒ 0.908) and on morphologic terms (к = 0.745–1.000). ConclusionThe CDT-VIBE sequence provides excellent spatial resolution and adequate image quality in ultra-fast breast DCE-MRI. Further improvement in PAT noise and internal structure blurriness may be necessary.