Abstract
CASE REPORT A 70-year-old man presented to our hospital with 18 months of cough and breathlessness. He was tachypneic and had decreased breath sounds and coarse crackles over his left chest. He was human immunodeficiency virus-negative and had never smoked. The 6-minute walk test revealed blood oxygen desaturation from 94% to 86%. The patient was admitted to the hospital for further tests and monitoring to establish a diagnosis. A radiograph of the patient’s chest showed inhomogeneous opacity in left mid and left lower zones (Figure 1). A high-resolution computed tomography (HRCT) scan done one year before presentation highlighted a classic “crazy-paving” pattern, where thickened interlobular septa and intralobular lines, with distinct geographic margins on a background of ground-glass opacification, could be seen in the left upper lobe (Figure 2A). HRCT performed on presentation showed that in the intervening year the lesion had increased dramatically along with minimal left-side pleural effusion (Figure 2B). Sputum stains and cultures for Mycobacterium tuberculosis, fungi, and other aerobic organisms were negative. Fiberoptic bronchoscopy showed no gross abnormality. Bronchial aspirate was negative for all organisms, as was the GeneXpert test for M tuberculosis. Transbronchial biopsy confirmed bronchioloalveolar carcinoma (BAC) (Figures 3A and 3B). These investigations were carried out during the patient’s five-day stay in our institution. After confirmation of the diagnosis, he was referred to a tertiary oncology center for further management and was lost to follow-up. DISCUSSION The first-ever portrayal of crazy-paving on HRCT was recorded in a patient with pulmonary alveolar proteinosis and is still considered a hallmark of the disease.1 Since then, a number of clinical conditions have been associated with this radiologic pattern visible on HRCT.2 This pattern has also been reported in viral/opportunistic infections, Pneumocystis carinii pneumonia, exogenous lipoid pneumonia, diffuse alveolar haemorrhage, and sarcoidosis.3 The crazy-paving pattern appears on HRCT as diffuse ground-glass opacification superimposed with interlobular septal thickening and intralobular lines in a geographic distribution resembling irregularly laid cobblestones. These areas are usually bilateral and feature distinct margins, which sharply demarcate these areas from the normal lung parenchyma.3,4 It has been postulated that the crazy-paving pattern occurs because of processes that cause alveolar filling, because of interstitial fibrosis, or because of a combination of both of these elements.2 BAC, a term coined by Liebow in 1960,5 accounts for approximately 4%
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