Abstract
Natural killer (NK) cell-mediated cytotoxicity involves both activating and inhibiory receptors. Recent studies indicated that an inhibitory type of activation mechanism determines NK target specificity and this has been strengthened by the identification of MHC class I-specific inhibitory receptors on NK [1]. Accordingly we demonstrated, using tumor cell variants derived from the BW5147 mouse T-cell lymphoma, a positive correlation between MHC class I H-2Dk expression and enhanced metastatic capability, which seems to be controlled by NK cells. Indeed, BW cells can escape from NK-cell-mediated killing by expressing H-2Dk molecules, that negatively regulate NK lytic activity [2,3].KeywordsNatural KillerNatural Killer CellCostimulatory MoleculeNatural Killer ActivityCostimulatory SignalThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call