Abstract
ObjectivesThree biallelic polymorphisms at the promoter region of the interleukin-10 (IL-10) gene have been associated with susceptibility to schizophrenia. The aim of this case-control study was to investigate the association between IL-10 (−1082) G/A gene polymorphisms and schizophrenia among Bataknese, a native tribe inhabiting the North Sumatera province in Indonesia. MethodsA total of 194 unrelated participants (n = 97 for each case and control groups) participated in this study. Polymerase chain reaction restriction fragment length polymorphism molecular genotyping was conducted to assess the genotype and allele distribution of IL-10 (−1082 G/A). ResultsAllele variations indicated that the dominant allele in the Batak tribe was allele A, whereas homozygous GG genotypes were not found in either group. The A allele and AA genotype were found to be risk factors for developing schizophrenia (OR = 2.26, 95% CI = 1.1825–4.3559 and OR = 2.56, 95% CI = 1.280–5.152, respectively). ConclusionOnly the A allele and AA genotype of the IL-10 gene polymorphism at −1082 G/A contribute to schizophrenia susceptibility in Bataknese.
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