IJCM_41A: Epidemiology of intussusception hospitalization and its potential risk with Rotasiil among vaccinated children admitted in a tertiary care hospital in South India

Abstract

Background: There is an established well reported link of intussusception with the use of rotavirus vaccines. Little is known about the newly introduced rotasiil vaccine causing intussusception. So, this study has been undertaken to study the epidemiology of intussusception and its potential risk among children vaccinated with Rotasiil vaccine. Methodology: A hospital based cross-sectional study was conducted for a period of 2 years among children <2 years admitted with confirmed intussusception. A predesigned semi structured questionnaire was used to capture sociodemographic data by interviewing parents and clinical data was collected from hospital records. Vaccination details was extracted from vaccination cards. Data was expressed in percentages and proportions. Results: Out of 80 confirmed cases of intussusception 64 (80%) children received rotasiil vaccine. The mean age of the study participants was 12+ 6 months and 67.5% of them were males. Out of the vaccinated children 82.8% and 98.4% of them had received all the doses and only two doses respectively. The median age (IQR) of receiving first, second and third doses was 7.6 (6.9-9.4), 12.9 (11.9-15.4), and 17.9 (16.4-21.8) weeks, respectively. Among them 95.3% of participants had ileocolic type of intussusception and 89% of it was resolved by non-surgical procedures. Within a risk period of 1-21 days postvaccination 1 and 8 cases of intussusception were reported after second and third dose respectively Conclusion: There were more number of cases of intussusception observed in the high risk period of 1-21 days after the third dose as compared to that of first and second dose of rotasiil vaccine