нigh prevalence of atherosclerosis comorbidity and his risk factors in patients with psoriatic arthritis compared to psoriasis without arthritis: A retrospective dermatological clinic-based study

Abstract

Background and Aims : An association between atherosclerosis and psoriasis (PsO) has still limited data. Objectives: to evaluate the prevalence of atherosclerosis comorbidity and his risk factors in patients (pts) with psoriatic arthritis (PsA) compared to PsO without arthritis in a dermatological hospital cohort.Methods: 765 pts (Male-439/Female-326) with moderate-to-severy plaque PsO, age PSO pts 52.4±15,6 years were included. 274 out of 765 pts (35.8%) had PsA and 491 out of 765 pts (64.2%) had PsO alone. PsA pts were older then PsO pts – 55.3±13.7 and 50.4±17,6 (p<0.001).Results: Atherosclerosis coding as I 70 were registered often in PsA pts compared to PsO pts – in 40 out of 274 pts (14.6%) and in 35 out of 491 pts (7.3%) accordingly (p<0.001). Smoking patients was found often in PsO pts compare to PsA pts – in 230 out of 491 pts (46.9%) and in 101 out of 274 pts (36.9%) accordingly (p<0.05). In PsA pts AH coding as I 10 - I 15 was found in more cases than in PsO pts - in 260 out of 491 PsO pts (52.8%) and in 187 out of 274 PsA pts (68.2%) accordingly (p<0.001). Obesity coding as Е65-Е68 was identify in 102 out of 765 pts (13.3%). Obesity were found in more cases in PsA pts - in 53 out of 491 PsO pts (10.9%) and in 49 out of 274 PsA pts (17.9%) accordingly (p<0.001).Conclusions: Atherosclerosis found increased frequency in PsA than PsO due to share inflammation pathways between atherosclerosis and PsA. Background and Aims : An association between atherosclerosis and psoriasis (PsO) has still limited data. Objectives: to evaluate the prevalence of atherosclerosis comorbidity and his risk factors in patients (pts) with psoriatic arthritis (PsA) compared to PsO without arthritis in a dermatological hospital cohort. Methods: 765 pts (Male-439/Female-326) with moderate-to-severy plaque PsO, age PSO pts 52.4±15,6 years were included. 274 out of 765 pts (35.8%) had PsA and 491 out of 765 pts (64.2%) had PsO alone. PsA pts were older then PsO pts – 55.3±13.7 and 50.4±17,6 (p<0.001). Results: Atherosclerosis coding as I 70 were registered often in PsA pts compared to PsO pts – in 40 out of 274 pts (14.6%) and in 35 out of 491 pts (7.3%) accordingly (p<0.001). Smoking patients was found often in PsO pts compare to PsA pts – in 230 out of 491 pts (46.9%) and in 101 out of 274 pts (36.9%) accordingly (p<0.05). In PsA pts AH coding as I 10 - I 15 was found in more cases than in PsO pts - in 260 out of 491 PsO pts (52.8%) and in 187 out of 274 PsA pts (68.2%) accordingly (p<0.001). Obesity coding as Е65-Е68 was identify in 102 out of 765 pts (13.3%). Obesity were found in more cases in PsA pts - in 53 out of 491 PsO pts (10.9%) and in 49 out of 274 PsA pts (17.9%) accordingly (p<0.001). Conclusions: Atherosclerosis found increased frequency in PsA than PsO due to share inflammation pathways between atherosclerosis and PsA.