Abstract
The role of IgG4 as well as the other subclasses of human IgG in allergic disease is not clear. Human IgG subclasses have been reported to be involved in various immune diseases. The immune response (cellular and humoral) appears to depend on the nature of the antigen, the amount of exposure as well as genetic factors. This article describes IgG4 and the immune system, first by comparing immunoglobulin structure, physicochemical, biologic properties as well as genetic markers of the four classes of human IgG immunoglobulins. The next portion of this article describes the influence of humoral and cellular immunologic factors that lead to the production of the four classes of IgG immunoglobulins. The relationship between antibody levels and various immune diseases is also described. The last portion of this article deals with the role of IgG4 in two aspects of allergic disease, namely (1) the immunopharmacologic response of basophils and mast cells and IgG4 antibodies and (2) biosynthesis of IgG4 in relation to IgE synthesis. The role(s) of IgG4 antibodies as skin-sensitizing or protective in allergic disease is described with regard to both aspects of allergic disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
