Abstract
The objective of this study was to determine the associations between insulin-like growth-factor-binding protein 7(IGFBP7) concentrations and concentrations of troponin T(TnT), N-terminal pro-B-type natriuretic peptide(NT-proBNP) and the parameters of kidney function in patients with stable ischemic heart disease(IHD). The IHD group consisted of 88 patients, and the population group comprised 66 subjects without a history of IHD. IGFBP7, TnT and NTproBNP concentrations were measured. The IGFBP7 value was considerably higher in the IHD group (1.76 ± 1 ng/mL vs. 1.43 ± 0.44 ng/mL, respectively, p = 0.019). Additionally, IHD subjects had a significantly higher concentration of TnT and NTproBNP. In both groups there was a significant correlation between IGFBP7 and serum parameters of kidney function (creatinine concentration: population gr. r = 0.45, p < 0.001, IHD gr. r = 0.86, p < 0.0001; urea concentration: population gr. r = 0.51, p < 0.0001, IHD gr. r = 0.71, p < 0.00001). No correlation between IGFBP7 and microalbuminuria or the albumin to creatinine ratio in urine was found. Moreover, there was a significant correlation between IGFBP7 concentration and markers of heart injury/overload-TnT and NT-BNP(r = 0.76, p < 0.001 and r = 0.72, p < 0.001, respectively). Multivariate regression analysis in joint both revealed that the IGFBP7 concentration is independently associated with urea, creatinine and TnT concentrations (R2 for the model 0.76). IHD patients presented significantly higher IGFBP7 concentrations than the population group. Elevated IGFBP7 levels are associated predominantly with markers of kidney function and myocardial damage or overload.
Highlights
Ischemic heart disease (IHD) contributes to both heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) and it is related with a poor prognosis [1]
In our research we focused on insulin-like growth-factor-binding protein 7 (IGFBP7), which interacts with IGF-1 and with insulin
The aim of the study was to determine the associations between IGFBP7 concentrations and concentrations of troponin T, NT-proBNP and serum parameters of kidney function in patients with stable IHD
Summary
Ischemic heart disease (IHD), due to the declining prevalence of hypertension and valvular heart disease, is the most common cause of heart failure (HF) in developed countries [1,2]. IHD globally affects around 126 million individuals (1655 per 100,000), which is approximately 1.72% of the world’s population, and its prevalence is rising [3]. IHD contributes to both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) and it is related with a poor prognosis [1]. Assess and monitor patients with HF and IHD, markers of heart injury are measured. The most common are troponin T (TnT) and NTproBNP
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