Abstract
The link between schizophrenia (SCZ) and type 2 diabetes mellitus (T2DM) has been known for many years. Recent investigations suggested the contribution of insulin resistance to both disorders. Hence, the present investigation is aimed to determine the possible link between three IGF2BP2 polymorphisms and the susceptibility to either SCZ or T2DM in the Iranian population. In this case-control study, 878 subjects were recruited. Genotyping of rs1470579, rs4402960, and rs11705701 polymorphisms was performed using the tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS–PCR) method. We found a significant link between dominant and recessive inheritance patterns of the two intronic IGF2BP2 variants (rs1470579, rs11705701) and SCZ or T2DM (P < .05). Strong linkage disequilibrium (LD) was noticed between rs1470579 vs. rs11705701 variants. We found that AGA, AGG, ATA, and CTG haplotypes were more frequent in patients with T2DM as compared with controls (P < .001). Regarding the CGG and CTA haplotypes, significant differences were found with 4.3 and 3.5 fold increase in SCZ patients compared to controls (P < .001). Besides, interactions between these variants influenced T2DM or SCZ susceptibility. These results recommend that rs11705701 and rs1470579 gene polymorphisms are associated to either SCZ or T2DM. Haplotypes of IGF2BP2 non-coding SNPs and their interactions may influence susceptibility to both diseases. Examining the co-existence of the disorders in different ethnicities with a larger population is encouraged for further investigations.
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