IgE-binding and mast cell–activating capacity of the homologue of the major birch pollen allergen and profilin from Cannabis sativa

Abstract

Cannabis is a flowering plant in the family of Cannabaceae, and the most widespread species is Cannabis sativa. In the past decade, cannabis allergy (CA) has been recognized as an increasing health issue and its prevalence is likely underestimated because of cannabis's illegal status in many countries and the absence of reliable diagnostics. The clinical presentation of CA is very heterogeneous, varying from mild rhinoconjunctivitis, urticaria, and angioedema to life-threatening anaphylaxis. Not seldom, CA is associated with a broad cross-reactivity syndrome involving fruits, vegetables, nuts, cereals, and latex.