Abstract
IgE+ B cells in the pathogenesis of allergic asthma: fundamental but often forgotten
Highlights
As of 2012 the World Health Organization had declared asthma as the most common, non-infectious disease among children [1]
IgE has been established as an effective therapeutic target for the treatment of AA given its role in the pathogenesis of the disease; the trafficking and relative frequencies of memory B cell subsets that produce IgE have been sparsely explored
Considering currently published data, more studies need to be conducted on the frequencies and function of IgE+ B cells and IgE in the airways of allergic asthmatics to delineate their role in AA pathogenesis
Summary
As of 2012 the World Health Organization had declared asthma as the most common, non-infectious disease among children [1]. AA is further characterized as an IgE-mediated disease whereby inhaled allergens trigger type 2 inflammation by binding to membrane-bound IgE on the surfaces of mast cells and basophils. This induces the activation and release of inflammatory mediators and promotes clinical symptoms such as wheezing, coughing and shortness of breath (2; Figure 1). This allergen-induced, IgE-mediated inflammatory response has been shown to incite increased allergen-specific IgE in the airways of allergic asthmatics [3]. The role of B cells in the pathogenesis of allergic asthma will be highlighted and therapeutic implications for targeting IgE and IgE+ B cells will be explored
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