The role of macrophage polarization in allergic asthma

Abstract

Allergic asthma(AA) is a common chronic respiratory disease, which seriously affects people’s health. Macrophage is the most abundant immune cell group in lung tissue, and is involved in the pathogenesis of allergic asthma. The macrophages show different activation states and play different immune functions after being stimulated by different allergens, which is called macrophage polarization. The role of the polarization of macrophages, macrophages in the pathogenesis of allergic asthma, and the new concept of epigenetic change during the polarization of macrophages, including miRNAs, DNA methylation and histone modification, were mainly discussed in this review. All of this may regulate the polarization of the macrophage by regulating the expression of the cell signal and the marker gene, and then affecting the pathogenesis of the allergic asthma. This may be helpful for the immunotherapy strategy of the allergic asthma. Key words: Allergic asthma; Macrophage polarization; M1; M2