Abstract
If there is not one cure for schizophrenia, there may be many
Highlights
The diverse presentation of symptoms experienced by patients with schizophrenia is matched only by the complexity of the genetic architecture that underlies disease risk
Already it is possible to apply structural or functional brain measures to stratify patients based on the severity of disease and/or drug response[11,12,13]
An emerging platform involves reprogramming of patient somatic cells to human induced pluripotent stem cells, in order to empirically test pharmacological response of patient-derived brain cells in vitro[16]
Summary
The diverse presentation of symptoms experienced by patients with schizophrenia is matched only by the complexity of the genetic architecture that underlies disease risk. We foresee a not-too-distant future whereby a combination of patient genotype, brain imaging and biomarkers efficiently pairs patients to their ideal drug. Already it is possible to apply structural or functional brain measures to stratify patients based on the severity of disease and/or drug response[11,12,13].
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