Abstract
Background: Wuhan Huanan seafood wholesale market is highly suspected as the original place for the outbreak of SARS-CoV-2 previously. Most studies focus on the livestock being sold in the market, neglecting that the livestock living around the city of Wuhan could also be the original hosts. Methods: First, relative synonymous codon usage was utilized to analyze the potential hosts of SARS-CoV-2; Then cluster SARS-CoV-2 and related coronavirus through the phylogenetic tree. Next, we used Recombination Detection Program to identify the possible recombination region, as well as verifying via Simplot. Results: Related coronavirus from porcine or murine sources may faciliatate the evolution and reorganization of SARS-CoV-2. Conclusions: Overall, to our knowledge, this is the first paper to illustrate that swine and mice could be probable reservoirs for the SARS-CoV-2.
Highlights
A novel coronavirus, SARS-CoV-2, was recently reported in the city of Wuhan, Hubei province, China, causing severe respiratory diseases as well as epidemic all around the China
Geographical hot map The distribution of Porcine epidemic diarrhea virus (PEDV) with Geographical heat map indicated the risk of pandemic of porcine epidemic diarrhea in different regions[10] (Figure 1)
We believe that the outbreak of SARS-CoV-2 is associated with porcine coronavirus to some extent
Summary
A novel coronavirus, SARS-CoV-2, was recently reported in the city of Wuhan, Hubei province, China, causing severe respiratory diseases as well as epidemic all around the China. On 29th February, 573 new confirmed cases of novel coronavirus infection were reported on the Chinese mainland, bringing the total to 78,630. Consensus that the SARS-CoV-2 originated from bats has been reached[2]. Wuhan Huanan seafood wholesale market is highly suspected as the original place for the outbreak of SARS-CoV-2 previously. Most studies focus on the livestock being sold in the market, neglecting that the livestock living around the city of Wuhan could be the original hosts. Results: Related coronavirus from porcine or murine sources may faciliatate the evolution and reorganization of SARS-CoV-2. Conclusions: Overall, to our knowledge, this is the first paper to illustrate that swine and mice could be probable reservoirs for the SARS-CoV-2
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