Abstract
Background: Previously, most studies focus on the wild animal being sold in the Wuhan Huanan seafood wholesale market, neglecting that the livestock living around other place could also be the original hosts. Methods: First, relative synonymous codon usage was utilized to analyze the potential hosts of SARS-CoV-2; Then cluster SARS-CoV-2 and related coronavirus through the phylogenetic tree. Next, we used Recombination Detection Program to identify the possible recombination region, as well as verifying via Simplot. Results: Related coronavirus from porcine or murine sources may faciliatate the evolution and reorganization of SARS-CoV-2. Conclusions: Overall, to our knowledge, this is the first paper to illustrate that swine and mice could be probable reservoirs for the SARS-CoV-2.
Highlights
Most studies focus on the wild animal being sold in the Wuhan Huanan seafood wholesale market, neglecting that the livestock living around other place could be the original hosts
The intermediate animal reservoirs of the SARS-CoV-2 point to swine and mice relative synonymous codon usage (RSCU) has been widely utilized to analyze the association between virus and potential host[7]
The Euclidean distance between Sus scrofa and SARS-CoV-2 is minimal, hinting that SARS-CoV-2 could effectively use porcine translation machinery better than that of other animals, suggesting that the epidemic SARS-CoV-2 might originate from swine
Summary
Most studies focus on the wild animal being sold in the Wuhan Huanan seafood wholesale market, neglecting that the livestock living around other place could be the original hosts. Methods: First, relative synonymous codon usage was utilized to analyze the potential hosts of SARS-CoV-2; cluster SARS-CoV-2 and related coronavirus through the phylogenetic tree. We used Recombination Detection Program to identify the possible recombination region, as well as verifying via Simplot. Results: Related coronavirus from porcine or murine sources may faciliatate the evolution and reorganization of SARS-CoV-2. Conclusions: Overall, to our knowledge, this is the first paper to illustrate that swine and mice could be probable reservoirs for the SARS-CoV-2. Any reports and responses or comments on the article can be found at the end of the article
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