Identification of Significantly Expressed Gene Mutations for Automated Classification of Benign and Malignant Prostate Cancer.

Abstract

Among males, prostate cancer (Pca) is the cancer type with the highest prevalence and the second leading cause of cancer deaths. The current screening methods for prostate cancer lack effectiveness such as prostate-specific antigen (PSA) and digital rectal exam (DRE). Machine learning models have been used to predict Pca progression, Gleason score, and laterality. In this research paper, we have employed novel Machine learning techniques such as Bayesian approach, Support vector machines (SVM), Decision Trees, Logistic Regression, K-Nearest Neighbors, Random Forest and AdaBoost for detecting malignant prostate cancers from benign ones. Moreover, different feature extracting strategies are proposed to improve the detection performance and identify potential genomic biomarkers. The results show the Lasso feature set yielded high performance from the models with SVM achieving exemplary classification accuracy of 97%. The Lasso and SVM combination reported many significant biomarker genes and gene mutations including but not restricted to CA2320112, CA2328529, and CA2436168.