Abstract

Identification of PP1 as the First Phosphatase for IRF7

Highlights

  • Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I IFNs

  • While there are a panel of kinases have been identified for IRF7 phosphorylation, no phosphatase has been reported for IRF7 dephosphorylation that may play a pivotal role in turning off IFN production

  • We have recently addressed this critical question by identification of protein phosphatase 1 (PP1) as the first phosphatase for IRF7

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Summary

Introduction

Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I IFNs. *Corresponding author: Ling Wang, Center of Excellence for Inflammation, Infectious Diseases and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, USA, Tel: 423-439-8063; E-mail: wangl3@etsu.edu Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I IFNs. The IFN production has to be turned off soon after infection.

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