Abstract
Cancer is a serious disease responsible for many deaths every year in both developed and developing countries. One reason is that the mechanisms underlying most types of cancer are still mysterious, creating a great block for the design of effective treatments. In this study, we attempted to clarify the mechanism underlying esophageal cancer by searching for novel genes and chemicals. To this end, we constructed a hybrid network containing both proteins and chemicals, and generalized an existing computational method previously used to identify disease genes to identify new candidate genes and chemicals simultaneously. Based on jackknife test, our generalized method outperforms or at least performs at the same level as those obtained by a widely used method - the Random Walk with Restart (RWR). The analysis results of the final obtained genes and chemicals demonstrated that they highly shared gene ontology (GO) terms and KEGG pathways with direct and indirect associations with esophageal cancer. In addition, we also discussed the likelihood of selected candidate genes and chemicals being novel genes and chemicals related to esophageal cancer.
Highlights
Esophageal cancer refers to tumors located in the region from the esophagus between the throat and stomach and has become the eighth most common cancer in recent years
We attempted to simultaneously identify novel genes and chemicals related to esophageal cancer
Based on known genes and chemicals related to esophageal cancer, we searched for new candidate genes and chemicals by applying a shortest path algorithm to the hybrid interaction network
Summary
Esophageal cancer refers to tumors located in the region from the esophagus between the throat and stomach and has become the eighth most common cancer in recent years. Symptoms of esophageal cancer include difficulty in swallowing and vomiting blood. Based on data from SEER 18 2004–2010, the five-year survival rate of this cancer was approximately 17.5% [1]. Identification of Genes and Chemicals Related to Esophageal Cancer. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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