Identification of molecular markers in patients with hypertensive heart disease accompanied with coronary artery disease.

Abstract

We investigated the plasma hypersensitive C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), and apelin levels in patients with hypertensive heart disease (HHD) plus coronary artery disease (CAD). Patients with hypertension hospitalized in Xuzhou Central Hospital were categorized into the HHD group and the HHD plus CAD group; 40 healthy subjects served as the control group. hs-CRP expression was determined with chemiluminescence. The expression of ox-LDL and apelin was analyzed with enzyme-linked immunosorbent assay. HHD was chiefly responsible for left atrial enlargement (P < 0.05) and left ventricle diastolic function insufficiency (P < 0.05). hs-CRP and ox-LDL were significantly higher in the HHD group than in the control group (P < 0.05). Compared with the control and HHD groups, significant increases in hs-CRP and ox-LDL levels were observed in the HHD plus CAD group. Apelin expression significantly decreased in the HHD group compared with that in controls (P < 0.05). Meanwhile, apelin expression significantly decreased in the HHD plus CAD group compared with that in the HHD (P < 0.05) and control (P < 0.05) groups. Logistic regression analysis for the binomial response variable indicated that high systolic pressure/diastolic pressure, increase in hs-CRP level, and decrease in apelin concentration were the risk factors for hypertension and cardiac impairments. HHD plus CAD has a greater influence on cardiac function than HHD alone. Increased inflammation and oxidative stress, as well as decreased secretion of cardiac protective factors, may be associated with the simultaneous onset of HHD and CAD.