Abstract
Introduction: Atrial fibrillation (AF) is prevalent in patients with hypertrophic cardiomyopathy (HCM). However, structural remodeling of the left atrium (LA) and pulmonary veins (PV) has rarely been investigated in this setting. This study aimed to identify differences in LA and PV remodeling between HCM and hypertensive heart disease (HHD) using 3D-CT. Methods: Included in this study are 33 patients with HCM, 25 patients with HHD, and 29 patients without any co-morbidities who were referred for catheter ablation of AF. ANP and BNP levels before ablation and Troponin T level after ablation were measured, and LA and PV diameters were 3-dimensionally determined. Results: LA diameters in the control group was shorter than that in the HHD or HCM group (Fig 1). The PV diameters were the longest in the HCM group (Fig 2). The PV/LA ratio was higher in the HCM group than the control or HHD group (PV-dominant remodeling) (Fig 3). All biomarkers were the highest in the HCM group (Fig 4). Conclusions: The stiff LA caused from atrial hypertrophy may account for higher levels of biomarkers and PV-dominant remodeling in HCM.
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