Abstract
ABSTRACT In this study, 16 marine shellfish proteins were selected for in silico hydrolysis. The binding abilities of the obtained oligopeptides to the two targets (COVID-19 spike protein and type 2 diabetes mellitus-related alpha-glucosidase) were evaluated. The results showed that 3 oligopeptides (PICQF, VIDVW, SVGPW) were identified as dual binders to the two targets. The in vitro test confirmed their inhibitory activities on alpha-glucosidase (19.58%, 23.02%, and 21.09%, respectively), which are close to drug Acarbose (21.87%), at the concentration of 1.5 mM. In conclusion, some marine shellfish-derived oligopeptides could be used as lead compounds to design potential inhibitors against COVID-19 and T2DM.
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