Abstract
A non-destructive method for analyzing medicinal products (non-steroidal anti-inflammatory drugs, fluoroquinolones, acetylsalicylic acid, vinpocetine, tetracyclines) based on diffuse reflection of IR radiation using a smartphone and a device printed on a 3D printer is proposed. It was established that the diffuse reflection of IR radiation (850 nm) from tabletized medicinal products can be recorded using a smartphone camera. Blister packaging and tablet coating slightly reduce the intensity of the diffuse light reflection signal at a wavelength of 850 nm, as confirmed by a comparative analysis of colorimetric measurement results in medicinal product samples inside the packaging, outside the packaging, and on tablet fractures. A correlation between the analytical signal and the concentration of the active substance is observed regardless of the study variant. The data array was processed using principal component analysis (PCA), hierarchical cluster analysis (HCA), partial least squares regression (PLS), and least squares methods using PhotoMetrix PRO® software for smartphones. It is shown that these algorithms can identify drugs by their manufacturer and determine the concentration of active ingredients. The colorimetric signals from tablets of a single manufacturer form separate clusters on dendrograms created using the HCA algorithm. Data obtained using PCA indicate the location of signals from tablets of different manufacturers in separate quadrants, facilitating the identification of the pharmaceutical company. The use of chemometric analysis methods for determining the concentration of the active substance is considered.
Published Version
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