Abstract
AimsPrevalence of prediabetes and type 2 diabetes mellitus(T2DM) are increasing worldwide. Key lncRNAs were detected to provide a reference for searching potential biomarkers of prediabetes and T2DM in hypertriglyceridemia patients.MethodsThe study included 18 hypertriglyceridemia patients: 6 newly diagnosed type 2 diabetes patients, 6 samples with prediabetes and 6 samples with normal blood glucose. Weighted gene co-expression network analysis (WGCNA) was conducted to construct co‐expression network and obtain modules related to blood glucose, thus detecting key lncRNAs.ResultsThe green, yellow and yellow module was significantly related to blood glucose in T2DM versus normal controls, T2DM versus prediabetes, prediabetes versus normal controls, respectively. ENST00000503273, ENST00000462720, ENST00000480633 and ENST00000485392 were detected as key lncRNAs for the above three groups, respectively.ConclusionsFor hypertriglyceridemia patients with different blood glucose levels, ENST00000503273, ENST00000462720 and ENST00000480633 could be potential biomarkers of T2DM.
Highlights
Hyperglycemia promotes a variety of reactions, including oxidative stress and the formation of advanced glycosylated end products, which have been associated with structural and functional changes in blood vessels that eventually cause dysfunction of several organs, especially the heart, nerves, eyes, and kidneys [1]
Insulin resistance leads to the occurrence of hypertriglyceridemia
Based on the above characteristics of Weighted gene co-expression network analysis (WGCNA), we used it to construct a co‐expression network and obtain modules related to blood glucose, detecting key genes, and providing a reference for searching potential biomarkers of prediabetes and T2DM in hypertriglyceridemia patients
Summary
Hyperglycemia promotes a variety of reactions, including oxidative stress and the formation of advanced glycosylated end products, which have been associated with structural and functional changes in blood vessels that eventually cause dysfunction of several organs, especially the heart, nerves, eyes, and kidneys [1]. Prevalence of prediabetes is increasing worldwide and more than 470 million people will have. LncRNAs in T2DM for Hypertriglyceridemia prediabetes by 2030 [2]. Previous studies indicated that prediabetes was associated with an increased risk of coronary heart disease, stroke, and all-cause mortality [3]. It is estimated that the number of patients with diabetes were expected to increase to 693 million by 2045. Compared with people who do not have diabetes, T2DM patients have a 15% increased risk of all-cause mortality [5]. T2DM patients with hypertriglyceridemia usually have a higher prevalence of diabetic complications [7]. Whether from a public health perspective or a clinical perspective, prediabetes and T2DM patients with high triglycerides should be paid more attention
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