Abstract
In this Research Highlight, we summarized the results from a study by Wu etal. published in Nature Cell Biology which uncovered that asparagine (Asn), a non-essential amino acid in mammalians, is able to enhance the TCR-mediated activation and efficacy of CD8+ T cells towards tumour through lymphocyte-specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy.
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