Abstract
Lymphocyte Differentiation and Effector Functions
Highlights
An interesting feature of lymphocyte progenitors that migrate to the thymus is their potential to originate other lineages
NKT cells are lymphocytes generated in the thymus through contact with glycolipid loaded CD1dpresenting cells with a diverse function in modulating immune responses against self- and foreign antigens
Lymphocytes differentiate in primary lymphoid organs where they commit a lymphocytic lineage, express B or T cell receptors (BCR and TCR, resp.,), which are essential for cell survival and further maturation as well as function, and are selected according to their capacity of antigen recognition
Summary
An interesting feature of lymphocyte progenitors that migrate to the thymus is their potential to originate other lineages. NKT cells are lymphocytes generated in the thymus through contact with glycolipid loaded CD1dpresenting cells with a diverse function in modulating immune responses against self- and foreign antigens. Lymphocytes differentiate in primary lymphoid organs where they commit a lymphocytic lineage, express B or T cell receptors (BCR and TCR, resp.,), which are essential for cell survival and further maturation as well as function, and are selected according to their capacity of antigen recognition.
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