Abstract
Introduction:: Numerous clinical data and animal models demonstrate that many patients with neuropathic pain suffer from concomitant depressive symptoms. Methods:: Massive evidence from biological experiments has verified that the medial prefrontal cortex (mPFC), prefrontal cortex, hippocampus, and other brain regions play an influential role in the co-morbidity of neuropathic pain and depression, but the mechanism by which neuropathic pain induces depression remains unclear. Results:: In this study, we mined existing publicly available databases of high-throughput sequencing data intending to identify the differentially expressed genes (DEGs) in the process of neuropathic pain-induced depression. Conclusion:: This study provides a rudimentary exploration of the mechanism of neuropathic pain-induced depression and provides credible evidence for its management and precaution.
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