Abstract
Tebuconazole belongs to the group of triazole fungicides. As a systemic foliar fungicide it was widely used in agriculture for crops protection, such as barley, wheat, peanuts and orchard fruits. Associations between exposure to pesticides and health outcomes in humans, including different kinds of cancer were reported by several authors. Effects in immune, hematological, nervous, endocrine and reproductive systems have also been described. Data about genotoxic effects of pesticides are rarely reported. We are interested in the detection of structural and numerical aberrations in bovine peripheral lymphocytes using fluorescence in situ hybridization (FISH) in vitro. Three whole chromosome painting probes (WCPs), BTA1 for the bovine chromosome 1 (red colour), BTA 5 for chromosome 5 (green colour) and BTA 7 for chromosome 7 (red colour), as well, were used in experiments. Aneuploidy and unstable structural aberrations were detected more precisely than those seen in conventional chromosome aberrations assays, but only on the marked chromosomes could be analysed.
Highlights
Pesticides are among the most widely used chemicals throughout the world
We are interested in the detection of structural and numerical aberrations in bovine peripheral lymphocytes using fluorescence in situ hybridization (FISH) in vitro
Under conditions of our experiments none reciprocal translocations were found. It is well-known from the literature that several among the investigated triazole fungicides influence the activity of various cytochrome P450 enzymes
Summary
Pesticides are among the most widely used chemicals throughout the world. They include a great variety of substances different both in composition and properties with the purpose to kill, destroy or repel undesirable living organisms. 1999), which is evolutionarily conserved between plants, fungi, and animals. This enzyme is critical component for cholesterol synthesis and steroid biosynthesis in animals (Zarn et al, 2003). Our interest was directed towards the detection of the frequency of stable aberrations, which do not result in the loss of chromosome material and it is assumed to be heritable. For this purpose, we have use fluorescence in situ hybridization technique
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