Abstract
Isoflavones do it too! Enhancement of chloride ion flux at GABAA receptors by positive modulators is an important therapeutic strategy for the treatment of central nervous system (CNS)-related disorders. Benzopyran-4-one derivatives (isoflavones), identified by systematic structure-driven design, exhibit potent flumazenil-insensitive positive modulation at human recombinant α1β2γ2L receptors expressed in Xenopus oocytes.
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