Abstract
Human lens accumulates gangliosides in association with aging and senile cataract progression. In this study we purified and characterized five major gangliosides in human cataractous lenses. Structural analyses and immunological studies revealed the presence of ganglio-series gangliosides, GM3, GM2, GM1 and GDla, and a sialyl-Lewis x-containing neolacto-series ganglioside, NeuAc α 2-3Ga1 β1-4(Fuc α l-3)GlcNAc β 1-3Ga1β1-4Glc β1-l ceramide (IV 3NeuAcIII 3FucnLc4). Slow-moving gangliosides, although minor components, were also found to have sialyl-Lewis-related structures, based on anti-Lewis' antiserum binding to their asialo forms. However, sialyl-paragloboside, a possible precursor of the sialyl-Lewis x ganglioside, was not identified.
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