Abstract
Purpose: Transcriptome-wide analyses demonstrated FN1 is the highest expressed gene in articular cartilage and is significantly upregulated with ongoing OA pathophysiology. FN1 encodes fibronectin, a dimeric glycoprotein, particularly localized in the pericellular matrix directly surrounding the chondrocytes. Fibronectin mediates a wide variety of cellular interactions by binding to extra cellular matrix proteins and to chondrocytes via integrins. The main integrin-binding domain of fibronectin is the RGD motif, which binds multiple integrin heterodimers, including the classic fibronectin receptor integrin α5β1.
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