Abstract
Four polyphenols were isolated and purified from a brown alga Eisenia arborea. These phlorotannin compounds showed strong radical scavenging and some enzyme inhibitory activities. All of the compounds showed strong antioxidative, acetylcholinesterase and butyrylcholinesterase inhibitory, and tyrosinase inhbibitory activities at 100 μg/mL. Dieckol and PFF inhibited butyrylcholinesterase, a new target for the treatment of Alzheimer’s disease, very strongly even at 10 μg/mL, more strongly than AChE. These two compounds also effectively inhibited tyrosinase. These results support the potential of developing natural antioxidants and antidementia agents from the brown alga.
Highlights
Eisenia arborea is a dominant species of kelp that is found on the western Pacific coast of North America, from Vancouver Island, Canada south to Mexico's Isla Magdalena and Baja California, as well as in Japan
UV spectra were recorded with a HP8453 UV/VIS spectrophotometer. 1H (400 MHz) and 13C (100.6 MHz) nuclear magnetic resonance (NMR) spectra were recorded on a JNM-LA 400 instrument (JEOL) with chemical shift data in ppm relative to the solvent used
Silica gel 60 F254 coated on aluminum plates and ODS plate by Merck were used for thin layer chromatography (TLC) and column chromatography
Summary
Eisenia arborea is a dominant species of kelp that is found on the western Pacific coast of North America, from Vancouver Island, Canada south to Mexico's Isla Magdalena and Baja California, as well as in Japan. It can be commonly found from the midtidal areas stretching to the subtidal areas. Eisenia arborea with hollow stripes are believed to be evolved algae in order to increase their survival in harsh living conditions. They play a huge role in determining envi-. Described are the identification and biological activities of the chemical constituents in Eisenia arborea
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