Abstract
Osteoporosis is a kind of brittle bone disease, which is characterized by a reduction in bone mineral density (BMD). In recent years, a number of genes and pathophysiological mechanisms have been identified for osteoporosis. However, the genes associated with BMD remain to be explored. Toward this end, we integrated multiple osteoporosis microarray datasets to identify and systematically characterize BMD-related genes. By integrating the differentially expressed genes from three osteoporosis microarray datasets, 152 genes show differentially expressed between high and low BMD osteoporosis samples in at least two of the three datasets. Among them, 88 were up-regulated in high BMD samples and 64 were up-regulated in low BMD samples. The expression of ZFP36, JUNB and TMEM8A were increased at high BMD samples in all three datasets. Hub genes were further identified by co-expression network analysis. Functional enrichment analysis showed that the gene up-regulated in high BMD were enriched in immune-related functions, suggesting that the immune system plays an important role in osteoporosis. Our study explored BMD-related genes based on the integration of osteoporosis microarray data, providing guidance to other researchers from a new perspective.
Highlights
Osteoporosis, a common systemic bone disease, can lead to weak bones and increase the risk of fractures (Ensrud and Crandall, 2017; Wilson et al, 2017; Khosla et al, 2018)
To explore the key genes associated with bone mineral density (BMD), we downloaded three osteoporosis microarray datasets from NCBI Gene Expression Omnibus (GEO) database
In GSE56814, compared to the low BMD samples, there were more genes up-regulated in high BMD samples, while GSE56814 had more genes up-regulated in low BMD samples
Summary
Osteoporosis, a common systemic bone disease, can lead to weak bones and increase the risk of fractures (Ensrud and Crandall, 2017; Wilson et al, 2017; Khosla et al, 2018). Bone homeostasis depends on osteoclast absorption and osteoblast formation. The imbalance of this tightly coupled process can lead to the development of osteoporosis (Chen et al, 2018b). This process involves changes in a variety of signaling pathways, including MAPK signaling pathway, NF-κB pathway, Notch signaling pathway, etc. Notch signaling pathway regulates the differentiation and function of osteoblasts and osteoclasts and participates in the process of Analysis of Genes Underlying BMD bone reconstruction, activation of notch signaling pathway can inhibit glucose metabolism and osteoblast differentiation of bone marrow mesenchymal progenitor cells (Lee and Long, 2018)
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