IDDF2019-ABS-0062 Gastric hyperplastic polyps are associated with an increased risk of colorectal neoplasia in the chinese population

Abstract

Background There are rare studies which evaluated the relationship between gastric hyperplastic polyps and synchronous colorectal neoplasia. To address this issue, we performed this retrospective, case-control study. Methods Patients with sporadic gastric hyperplastic polyps who underwent colonoscopy simultaneously were consecutively enrolled. Each patient was compared with two randomly selected age and sex-matched controls without gastric polyps who also underwent colonoscopy in the same period in Changzhou No.2 people’s hospital between January 2015 and December 2017. The urease breath test or rapid urease test was used to determine H. pylori. Data of patient‘s demographics and characteristics of the gastrointestinal polyps were collected. Results This study involved 106 patients with gastric hyperplastic polyps and 212 age and sex-matched controls without gastric polyps among 4200 patients who underwent gastroscopy and colonoscopy simultaneously. There was no significant difference in tobacco smoking, alcohol drinking, Diabetes, H. pylori infection and blood lipids between the two groups (P>0.05). In the gastric hyperplastic polyp group, the prevalence of colorectal neoplasia which included adenoma and cancer was 29.2%; however, in the controls, the prevalence of colorectal neoplasia was 18.4%. There was a significantly higher rate of colorectal neoplasia (OR = 1.83, 95% CI = 1.06–3.16) in the gastric hyperplastic polyp group than in the control group. There was no significant difference in the size, number and distribution of colorectal neoplasia between the two groups (P>0.05). Further stratification analyses reveal that a significantly increased risk of colorectal neoplasia associated with hyperplastic polyps was evident among men (OR = 3.03, 95% CI = 1.39–6.61) and subjects with H. pylori infection (OR = 1.88, 95% CI = 1.01–3.54), compared with the control group. Conclusions The risk of colorectal neoplasia increases in patients with sporadic gastric hyperplastic polyps, especially in male and H. pylori infection patients, and a screening colonoscopy is necessary for these patients to detect colorectal neoplasia.