Abstract
Porous nanosilica (PNS) has been attracting a growing attention in fabrication of carriers for drug delivery system (DDS). However, unmodified PNS-based nanocarriers exhibit the initial burst release of encapsulated bioactive molecules, which may limit their potential clinical applications. In this report, the surface of PNS was conjugated with gelatin-poly (ethylene glycol) methyl ether (GEL-mPEG) to form a core-shell structure PNS-GEL-mPEG for doxorubicin (DOX) delivery. The conjugated PNS carriers were found to be spherical in shape with diameter range of approximately 55-85 nm as compared with their parentally PNS (55-67 nm). The PNS-GEL-mPEG nanoparticles showed their ability to effectively encapsulate DOX for controlled release. In detail, DOX was efficiently loaded into the PNS-GEL-mPEG to form DOX-loaded nanocarriers (DOX@PNS-GEL-mPEG) with high loading efficiency (79.7%). The release of DOX from DOX@PNS-GEL-mPEG was prolonged and controlled up to 96 h in phosphate buffered saline (PBS, pH 7.4, 37 oC) without any initial burst release. These results demonstrated that this PNS-GEL-mPEG can be a potential candidate for controlled DDS with high loading capacity in cancer therapy
Highlights
The surface of Porous nanosilica (PNS) was conjugated with gelatin-poly methyl ether (GEL-mPEG) to form a core-shell structure PNS-GEL-mPEG for doxorubicin (DOX) delivery
The conjugated PNS carriers were found to be spherical in shape with diameter range of approximately 55-85 nm as compared with their parentally PNS (55-67 nm)
DOX was efficiently loaded into the PNS-GEL-mPEG to form DOX-loaded nanocarriers (DOX@PNS-GEL-mPEG) with high loading efficiency (79.7%)
Summary
Gelatin-Poly (Ethylene Glycol) Methyl EtherFunctionalized Porous Nanosilica for Controlled Doxorubicin Delivery Uyen Vy Vo 1, 2, 3 , Tuong Vi Tran 1, 2, Ngoc Tram Nguyen Thi 1, 2, 4, Anh Khoa Nguyen 1, 2, 4, Bao Yen To Thi 1, 2, 5, Cuu Khoa nguyen 1,2, Dai Hai Nguyen 1, 2* 1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cay Giay, Hanoi 100000, Vietnam 2 Institute of Applied Materials Science, Vietnam Academy of Science and Technology 01 TL29, District 12, HCM
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