ID 218 – Dissociation of sleep quality and cognition in mild cognitive impairment and Alzheimer’s disease: Evidence from event-related potential study

Abstract

Objective Previous studies suggest that long-term changes in sleep may influence attention than short-term changes in duration of sleep. Sleep quality is more permanent indicator of sleep problem. While, the impact of sleep quality on sensory and cognitive processes is still unclear in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Cognitive event-related potentials (ERPs) are one of the most informative and dynamic methods of monitoring attentive and cognitive processes, especially in the temporal domain. The aims of the present study are to investigate the effect of sleep quality in cognition by event-related potentials in patients with MCI and AD. Methods Using the Cognitive Abilities Screening Instrument (CASI), Chinese version of the Pittsburg Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and P300 ERPs 42 patients with probable AD, 70 patients with MCI, and 92 controls were recruited. Results When the participants were stratified according to the PSQI and ESS, there was no difference in scores of CASI and all measurements of ERPs in controls and patients with MCI and AD. Conclusion Our findings suggest that there is no association between sleep quality and cognition by ERPs in patients with MCI and AD.