Abstract
Spinal cord stimulation (SCS) is a neurostimulation treatment for refractory chronic pain in which pulses of electrical current are applied to the dorsal spinal cord. SCS frequencies vary substantially between patients and SCS paradigms, and it is well known that frequency selection will affect patient satisfaction and analgesia. It is also well known that action potentials within complex axonal arbors may be subject to frequency-dependent transmission failure, and emerging evidence suggests that primary afferent terminations within the dorsal horn are prone to such failure at SCS-relevant frequencies. In this study, we used a computational modeling approach to investigate the fidelity of action potential propagation within primary afferent arbor terminations.
Published Version
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