Abstract
Brain networks responsible for seizure generation in drug resistant epilepsy vary dynamically before, during, and after seizures.[1] Electrographic state changes are important to characterize for efficacious interfacing of neuromodulators and brain networks when treating epilepsy with closed-loop neurostimulators. Specifically, the clinically defined seizure onset and propagation zones have shown to have high inward and low outward connectivity on stereotactic-EEG (SEEG) analyses during inter-ictal periods, perhaps representing inter-ictal inhibition of these regions.[2,3] Further characterization of directed connectivity during peri-ictal periods (pre-ictal, ictal, and post-ictal) could enhance neuromodulator feedback loop response to brain state changes and help inform electrical therapy, including predicting seizure onset.
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