Distance to criticality undergoes critical transition before epileptic seizure attacks

Abstract

Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures.