Abstract
Evoked compound action potentials (ECAPs) identified during spinal cord stimulation (SCS) in humans have been observed to closely correlate with the activation of the stimulation-induced sensory perception perceived as paresthesia1. We recently demonstrated feasibility of recording ECAPs from the spinal cord in naïve rats using uniquely designed equipment2. Here, we extended our experiments to provide electrophysiological characteristics of the response of dorsal column axons to SCS based on ECAPs recording in rats with neuropathic pain. Moreover, we demonstrate the ability to deliver ECAP-controlled closed-loop SCS in neuropathic pain rats, which has been proven superior to open-loop stimulation in humans3,4.
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