Abstract
The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of the genus Orthohepevirus include hepatitis E virus, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Extrahepatic manifestations of Guillain–Barré syndrome, neuralgic amyotrophy, glomerulonephritis and pancreatitis have been described in humans. Avian hepatitis E virus causes hepatitis–splenomegaly syndrome in chickens. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Hepeviridae, which is available at www.ictv.global/report/hepeviridae.
Highlights
The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses
The capsid is formed by capsomeres consisting of homodimers of a single capsid protein, forming the virus shell
Non-structural proteins encoded by the first ORF (ORF1) have limited similarity with the ‘alphalike supergroup’ of viruses and contain domains consistent with a methyltransferase, papain-like cysteine protease, macro domain, RNA helicase and RNA-dependent RNA polymerase [2]
Summary
The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. Typical member: Virion Genome Replication Translation Host range Taxonomy human hepatitis E virus Burma (M73218), species Orthohepevirus A, genus Orthohepevirus Non-enveloped, 27–34 nm diameter with a single capsid protein 6.4–7.2 kb capped positive-sense monopartite RNA containing three ORFs Occurs in association with the host endoplasmic reticulum From genomic (ORF1) and a subgenomic (ORF2 and ORF3) capped mRNA Mammals (Orthohepevirus A, C and D), birds (Orthohepevirus B) and trout (Piscihepevirus) Two genera
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