Abstract
A comparison of therapeutic regimens used in the treatment of testicular tumor was carried out utilizing a murine genital ridge graft model (Stevens) which provides an unlimited number of tumor foci of precisely known age, histologically similar to germinal testis tumor in human beings, and highly predictable in size and degree of differentiation. They arise de novo in vivo. The four drug combination of 5- fluorouracil, cyclophosphamide, methotrexate, and vincristine gave the greatest objective response of currently used regimens. The use of ICRF-159 was suggested by the incidental findings of damage to the spermatogenic cell line in early laboratory experiments. It was shown to be considerably more effective against murine testicular tumor using the Stevens model than all other regimens and acted synergistically with the four-drug regimen.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
