Abstract
This study was undertaken to establish the role of ICAM -1 levels and their correlation with cytokines (IL-1, IL-6 and TNF) production in the pathogenesis and in the clinical course of childhood ALL. A total number of 160 children with ALL, 96 boys and 64 girls, aged from 0.5 to 15 years was included into the study. ICAM-1 levels and IL-6 production were studied according to the conventional ELISA Genzyme-test, TNF production was studied in supernatants derived from 24 h PBSC mononuclear culture, according to the method based on growth inhibition of 929 mice fibroblasts sensitive to TNF, IL-1 production after the method based on inhibition of autologous rosette formation by thymocytes of CBA mouse. Thirty seven healthy children served as the control group. A correlation between ICAM-1 and TNF and IL-1 was observed, a decrease after start of chemotherapy of ALL being noted, while a relative increase of IL-6 was observed. It was found that in children with ALL the serum levels of ICAM-1 was higher, during the whole period of therapy while IL-1- production was significantly lower than that observed in the control group of healthy children (p < 0.005). After cessation of therapy ICAM-1, IL-1 and TNF production increased, while IL-6 production remained on the same level. During a 10-year period after the end of therapy median values of IL-1 did not reach the values of the control group.
Published Version
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