Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

J A Balleño,H Saade,E Mendizábal,N Rios-Donato,R G López,R Díaz De León-Gómez,A P Mendizábal-Ruiz

doi:10.1155/2018/4527203

J A Balleño, H Saade + Show 5 more

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https://doi.org/10.1155/2018/4527203

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Abstract

Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80–120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

Highlights

Drug-loaded nanostructures are a subject of increasing interest for a large number of research groups around the world
In contrast with our previous report on preparation of drug-loaded poly(ethyl cyanoacrylate) (PECA) nanoparticles, in which rifampicin was loaded once the particles were obtained [13], in this document we report the preparation of IB-loaded PECA nanoparticles by carrying out the semicontinuous heterophase polymerization (SCHP) in the presence of the drug, varying the surfactant concentration, pH, and temperature
In the spectrum of the PECA loaded with IB, the characteristic bands of the drug can be observed: the broad band between 2800 and 3200 cm−1, the signals between 750 and 900 cm−1, and the band at 1715 cm−1 of the carbonyl group at one side of the carbonyl group band of the PECA (1750 cm−1)

Summary

Introduction

Drug-loaded nanostructures are a subject of increasing interest for a large number of research groups around the world Some of their potential advantages for treatment of various diseases include controlled release, greater selectivity, longer times in the blood stream, decrease of side effects, and attenuation of multidrug resistance, which leads to an increase in the efficacy of the drugs [1,2,3,4]. Among the nanostructures used for drug loading, liposomes, inorganic particles, polymeric micelles, quantum dots, polysaccharide particles, dendrimers, and polymeric particles can be included [5, 6] Each of these types of nanostructures provides advantages and drawbacks for drug administration; polymeric nanoparticles perhaps are the ones with greater potential [7]. Plenty of papers in the specialized literature dealing with the preparation of drug-loaded polymer nanoparticles [7] report the obtaining of structures with diameters greater than 50 nm

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