Abstract
Background: IAC Yokohama system has 5 categories that may be stratified by their risk of malignancy (ROM) and supply guidance within a management algorithm for every category. The main objectives were to categorize the Breast FNAC samples according to new system of reporting and to assess the Risk of malignancy (ROM), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for all categories. Material and Methods: A total of 174 cases were prospectively studied over a period of one year from 1st November 2019 to 31st October 2020 in GMC, Jammu. All the FNAC received was reported routinely according to the newly proposed Yokohama system of reporting breast cytology. The ROM, sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and accuracy of Breast FNAC were calculated. Results: ROM is 0% for category 1, 2.27% for category 2, 50% for category 3, 50% for category 4 and 100% for category 5. Sensitivity, specificity, and diagnostic accuracy were, respectively, 100%, 100% and 99.11% for category A (only C5 category cases considered positive test results), 88.2%, 93.6%, and 93.6% for category B, (both C4 and C5 categories considered positive test results), and 94.1%, 91.48%, and 92.1% for category C (C3, C4, and C5 category cases grouped as positive test results). PPV and NPV were also calculated. Conclusion: Categorization of the Breast FNAB cytology according to IAC Yokohama system of reporting helps pathologist in the diagnostic clarity and guides clinician in the appropriate patient management.
Published Version
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