Abstract
Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer.
Highlights
The past several decades has determined the immune system plays an integral role in the pathogenesis and progression of human cancers
hypoxia-inducible transcription factors (HIFs) α subunits are hydroxylated by prolyl hydroxylase domain (PHD), containing enzymes on two proline residues, which reside in a N-terminal O2-dependent degradation domain
TAN recruitment and influx is critical for cancer initiation and progression and tumor hypoxia, through HIF-dependent secretion of cytokines is a major regulator of this process [39]
Summary
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