Abstract
Hypoxic preconditioning is able to increase the body’s resistance to hypoxic/ischemic stress. Understanding how to apply the hypoxic response to initiate the protective mechanism of ischemic preconditioning is a high priority. However, the relationship between innate resistance to hypoxic stress and preconditioning efficiency of moderate hypoxia has been poorly studied. In our work, the efficiency of single moderate hypobaric hypoxia (HBH) for resistance to severe hypobaric hypoxia (SHBH) was studied on intact rats and those pre-tested under SHBH with low, intermediate and high resistance to hypoxia. HBH has a significant preconditioning action on the resistance to hypoxia over a wide range from 270 to 1464 s (4.5 to 24.5 min) and at the same time eliminates the differences in the endurance under SHBH between all rat groups. It is concluded that 1) HBH preconditioning efficiency does not depend on an innate resistance to SHBH and prior hypoxic experience of rats; and 2) the pretesting to severe hypoxia has no value for predicting the hypoxic preconditioning efficiency and study of adaptive mechanisms.
Highlights
Short episodes of non-damaging stress impacts of different aetiologies are capable of increasing the body’s resistance to various pathological factors
It is concluded that 1) HBH preconditioning efficiency does not depend on an innate resistance to SHBH and prior hypoxic experience of rats; and 2) the pretesting to severe hypoxia has no value for predicting the hypoxic preconditioning efficiency and study of adaptive mechanisms
The pretesting under severe hypoxia was applied to rats for the investigation of mechanisms of hypoxic preconditioning [22] [23]. Using this pre-test, we found that a single session of moderate hypobaric hypoxia (HBH, 11% O2, 60 min) eliminated differences in the resistance to severe hypobaric hypoxia (SHBH, 4.5% O2) between the high- and low-resistant rats [29]
Summary
Short episodes of non-damaging stress impacts of different aetiologies are capable of increasing the body’s resistance to various pathological factors. The pretesting under severe hypoxia was applied to rats for the investigation of mechanisms of hypoxic preconditioning [22] [23] Using this pre-test, we found that a single session of moderate hypobaric hypoxia (HBH, 11% O2, 60 min) eliminated differences in the resistance to severe hypobaric hypoxia (SHBH, 4.5% O2) between the high- and low-resistant rats [29]. Since the resolution of this issue was directly related to the mechanisms of hypoxic preconditioning, a comparative study of the high-, intermediate- and low-resistant rats pre-tested under SHBH, and of the intact rats was carried out In these rat groups, the HBH influence was evaluated in the resistance to SHBH
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