Abstract
Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. Antihypoxant ethomersol administration (25 mg/kg, 3 days, intraperitoneally) following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. Monotherapy of consequences of craniocerebral trauma with antidepressant pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemithyl, an antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemithyl was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemithyl had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.
Highlights
Practical medicine needs in defense of the organism from oxygen insufficiency
The individual resistance of the body to acute hypoxia is of particular significance in the post-traumatic period, and its relationship with the typological characteristics of higher nervous activity and brain metabolism determines the direction of pharmacological correction of the consequences of craniocerebral trauma
The aim of the present work was to study the role of resistance to acute hypoxia in rats in the realization of the protective effects of ethomersol after craniocerebral trauma
Summary
Антигипоксант этомерзол (25 мг/кг, 3 дня внутрибрюшинно), введенный после травмы, уменьшал поведенческие расстройства у крыс с разным уровнем устойчивости к гипоксии, сохраняя структуру индивидуального поведения и предупреждая метаболические нарушения в головном мозге. Наиболее значимо защитный эффект бемитила проявлялся у крыс с высокой устойчивостью к гипоксии. Ключевые слова: устойчивость к гипоксии; антигипоксанты; черепно-мозговая травма; этомерзол; бемитил; пиразидол; поведение; метаболизм. An antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. Pyrazidol and bemithyl had an additive effect in animals of both groups They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain. Keywords: resistance to hypoxia; antihypoxants; craniocerebral trauma; ethomerzol; bemithyl; pyrazidol; behavior, metabolism
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