Abstract
Administration of the discontinued diphtheria-pertussis-tetanus vaccine was occasionally associated with a hypotonic-hyporesponsive episode in infants. The whole bacterial cell pertussis component was the likely culprit. For this reason, an acellular pertussis component was developed and incorporated into a new vaccine commonly called diptheria-tetanus-acellular pertussis (DTaP). Administration of DTaP vaccine has been followed by remarkably few hypotonic or hyporesponsive episodes. This report describes one of these unusual events.
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